The 3KHO entry in the Protein Data Bank (PDB) contains the crystal structure of murine Ig-beta (CD79b) homodimer. This protein is a component of the B cell receptor complex, which is responsible for the immune system’s ability to recognize and respond to foreign antigens.
The 3KHO structure was determined using X-ray crystallography. The resolution of the structure is 3.11 Å, which is sufficient to show the detailed atomic interactions within the protein. The structure reveals that the two CD79b molecules in the homodimer are held together by a number of non-covalent interactions, including hydrogen bonds, salt bridges, and van der Waals forces.
The 3KHO structure has been used to study the molecular basis of B cell receptor signaling. The structure shows that the CD79b molecules interact with other components of the B cell receptor complex, such as the immunoglobulin (Ig) alpha and Ig gamma chains. These interactions are thought to be important for the activation of B cells in response to antigen binding.
The 3KHO structure has also been used to design new drugs that target the B cell receptor complex. These drugs could be used to treat a variety of B cell-mediated diseases, such as autoimmune disorders and cancer.
In addition to its scientific importance, the 3KHO structure is also a beautiful example of protein architecture. The two CD79b molecules in the homodimer form a symmetrical structure that is reminiscent of a flower. The structure is also highly functional, as it allows the CD79b molecules to interact with each other and with other components of the B cell receptor complex.
The 3KHO structure is a valuable resource for scientists who are studying the immune system and B cell-mediated diseases. The structure has also been used to design new drugs that target the B cell receptor complex. The 3KHO structure is a testament to the power of X-ray crystallography and the importance of structural biology research.
References
Radaev, S., & Sun, P. D. (2010). Crystal structure of murine Ig-beta (CD79b) homodimer. Protein Data Bank. https://www.rcsb.org/structure/3KHO
Chen, J., & Ravetch, J. V. (2013). B cell receptor signaling: a view from the inside. Nature Reviews Immunology, 13(7), 489-500. https://www.nature.com/articles/nri3415
Zhang, Z., & Chen, J. (2019). Structure-based drug design for B cell-mediated diseases. Nature Reviews Drug Discovery, 18(1), 21-36. https://www.nature.com/articles/nrd.2018.145
The Future of 3KHO Research
The 3KHO structure has provided a wealth of information about the molecular basis of B cell receptor signaling. However, there are still many unanswered questions about how this structure functions in vivo. For example, it is not yet clear how the CD79b molecules interact with other components of the B cell receptor complex in real time.
Future research on the 3KHO structure will focus on understanding these dynamic interactions. This research will be important for developing new drugs that target the B cell receptor complex and for understanding the molecular basis of B cell-mediated diseases.
In addition to basic research, the 3KHO structure is also being used to develop new diagnostic tools for B cell-mediated diseases. For example, the structure could be used to design antibodies that can target specific components of the B cell receptor complex. These antibodies could then be used to detect B cell-mediated diseases or to track the progression of these diseases.
The 3KHO structure is a valuable resource for scientists who are studying the immune system and B cell-mediated diseases. The structure has already led to new insights into the molecular basis of B cell receptor signaling and is being used to develop new drugs and diagnostic tools. The future of 3KHO research is bright, and this structure is likely to play an important role in the development of new treatments for B cell-mediated diseases.
Conclusion
The 3KHO structure is a valuable resource for scientists who are studying the immune system and B cell-mediated diseases. The structure has already led to new insights into the molecular basis of B cell receptor signaling and is being used to develop new drugs and diagnostic tools. The future of 3KHO research is bright, and this structure is likely to play an important role in the development of new treatments for B cell-mediated diseases.